That's exactly what I'd want. Let a sim run in the upper right, type a module spec at the bottom, and the schematic is open in the upper left. The sim I only want to see when it has run its course and the schematic is only edited when a new idea comes to mind, or I must look at it occasionally and copy stuff out of it to write the module spec. No more fatigue than a 2-monitor setup but simpler.
It's like my desk. The surface is kept fairly clean so I have 6ft by 3ft workspace, plus overflow to the right. If not enough there's the same desk area behind me. This is where I often keep binders open and such. That's a lot more head movement than a 50" monitor. If I use the overflow behind me I must get out of the chair which is (medically) always a good thing.
Also, there is an old rule for us CAD jockeys: Don't set up your workplace to totally minimize movements. It's not at all good for your body.