I've used power JFETs as analog switches to isolate the driver amplifier output on a half duplex comms system. The amplifier drives maybe 500mA from a 50V supply using class B at up to 100kHz. Getting the necessary negative gate drive is easy as I can set and hold the amp output at 25V.
This is a simple and effective solution apart from the sheer size of these monsters. No-one makes power JFETs in small packages it seems and quantities are too small to consider custom.
Would a HEMT work here as a more-or-less drop in? I have absolutely no experience with these, but as far as I can tell, they don't have the substrate diode problem that makes a MOSFET tricky here.