The ISS is cool, but what we need is a huge, higher orbiting 'space platform' where we assemble the bigger birds meant for the moon, Mars, and beyond. There should be no thoughts of launching from earth for such missions when doing so from space increases useable payload enormously.
What we really should be doing is firing a few million tons of ice up to the moon for storage and to hedge against rising sea levels. We should also build huge, closed reservoirs down at our tropics as well, and fill them with polar ice. We have all that pure water, yet we still drink filter water table crap that we spent the last several decades damaging. That aside from the fact that the lazy asses do not filter it as well as they claim to.
Worry about the water. THEN worry about the Moon, and space, etc. The water is a HUGE problem.