I don't know what a "cutting edge" FPGA is other than a startup company. Is that risky... yes of course.
You are speculating about the foundry vs. FPGA. All foundries are used for "tons" of other products or they wouldn't stay in business. In fact, the FPGA companies are the customers that define the foundry business being the first real customers of the state of the art new fab lines.
FPGAs are among the longest lived complex semiconductor devices out there. You may find transitors, op amps and 8051s that live a lot longer, but you won't find much LSI that lives longer than FPGAs.
So? You can't find anything that competes with FPGAs in that technology.
Ok, but you are here because you are finding this approach to be a PITA because of all the accuracy issues.
Yes, some MCUs live for a while, but not 20 years. I have never seen an MCU other (than the 8051 and a few Mil/aerospace processors) that long. Why? Because no one wants them. They are old, slow and not cost effective. If you seriously need a 20+ year production life without redesign of any sort, then you will need to stick with 8051s and 4000 series CMOS. Is redesign really that big a problem that it can't be done every 10 years or so?
I have no idea what you base that on. If you ask them to make a part they have discontinued it will cost an arm and a leg. Just give it a thought for a bit. Running a fab is not cheap and making a run of parts is not done for less than how many thousands of chips?
And is that multiple sourced and long lived.. I doubt it. Even so, 100 MHz 8051 won't do this job without some analog support which takes you back to your accuracy problems.
Who was it that said things should be done as simply as possible, but no further. You are here because the analog approach is not so simple due to the... well, analog effects.