What matters most to me is that the mental design process is not slowed down by the mechanics of CAD schematic entry. Design is the real work.
We size our library parts and fonts so the schematics look good printed on B size (11x17") paper. We have a great Sharp color copier that's networked, and prints B size too. Toner comes in buckets.
PADS doesn't support colors or layers on schematics, and I don't like to clutter released schematics with notes that can't be hidden. But my D size vellum originals are decorated with notes, calculations, and waveforms; I never throw them away.