A few quick comments; I've only used Protel, Accel, OrCAD, and PADS.
Protel: If you find a "stable" version, it's actually pretty good and the price is right. Unfortunately, there are often main unstable, buggy-as-all-get-out versions inbetween the good ones! Protel runs schematic capture, PCB layout, SPICE simulation, etc. all within its own window. This makes it feel "well integrated."
Accel: Bah. Gets the job done, not as "user friendly" as Protel, but has better database connectivity if you want to extract design details externally. Accel feels a lot like a "design by committe" -- on paper it looks quite good, but in practice it's spendy for what you get and doesn't feel particularly "slick."
OrCAD: OrCAD seems to be in serious need of some _good_ programmers (as well as some good technical writers!). Things like tree view hierarchies don't support, say, renaming "in place" (selecting a line item and hitting F2 to rename it), the hierarchy itself is somewhat "fixed" and not completely "free form" (i.e., you can add any type of files you feel like) like most newer development environments are, etc. OrCAD's strength is its database connectivity -- this seems somewhat better documented and developed than other tools. Likewise, the strong database backend lets you do some pretty nice "multi-select editing" in one fell sweoop. Still, for the price I think OrCAD is not very impressive -- I'd almost bet a nickel that OrCAD is one of the slowest growing packages out there these days and that OrCAD is more just banking on the users they've had for years and years -- ten years ago, OrCAD
386 was a sight to behold!
PADS: I don't have that much experience with it yet, but their motto of being "designed to meet the needs of the power user while keeping the beginner is mind" strikes me as fitting. It really does seem to have more "power tools" than Accel or OrCAD (and probably Protel, but Protel made it pretty easy to write your own extensions if you wanted to). So far I like it... but I'm not having to pay for the license!
So far Protel is my favorite, but with more experience I might shift towards PADS. Pulsonix does look very attractive, but I've never had the opportunity to use it.
Unless you have plenty of money around, I'd suggest starting out with one of the cheaper schematic capture/PCB layout packages (something preferably under $1K?) to see what you like and don't like. Or even use some of the free packages for some "trial" project, and then get a few 30 day free evals from the commercial vendors to see what you like. I've been quite impressed with how sophisticated some projects on the really cheap and even free packages are.
---Joel Kolstad