Data from the UK?s Phase 3 trial for the jab showed the new variant was detected in more than half of the Covid-19 cases recorded, with the va ccine candidate shown to be 95.6 per cent effective against the original st rain and 85.6 per cent effective against the variant.
The study involved more than 15,000 participants aged 18 to 84, with 27 per cent aged over 65.
Loss of effectiveness due to variant is obviously because their spike antig en was not optimized for it, but the results are still in the WOW category.
The advanced purchase price agreements entered into thus far has been aroun d $6 per dose. Australia is completely sold on it on the basis of their exp erience in trials there and the advice of their senior immunologists, and r ecently ordered an additional 10 million doses. No extraordinary storage te mperatures required.
NOVAVAX does not mess around cherry picking volunteers for best showing. Th ey get everyone, young, old, healthy, infirm, immunocompromised, chronicall y ill... Why? Because they want a scientific measure of how well the vaccin e will perform in the general population with no surprises.
This is protein subunit vaccine. No RNA or infective adenovirus or any othe r radical measure is used. Other subunit vaccines are already in widespread use. Examples include the hepatitis B and acellular pertussis vaccines (protein subunit), the pneumoc occal polysaccharide vaccine (polysaccharide), and the MenACWY vaccine, whi ch contains polysaccharides from the surface of four types of the bacteria which causes meningococcal disease joined to diphtheria or tetanus toxoid ( conjugate subunit).
nt was detected in more than half of the Covid-19 cases recorded, with the vaccine candidate shown to be 95.6 per cent effective against the original strain and 85.6 per cent effective against the variant.
er cent aged over 65.
igen was not optimized for it, but the results are still in the WOW categor y.
und $6 per dose. Australia is completely sold on it on the basis of their e xperience in trials there and the advice of their senior immunologists, and recently ordered an additional 10 million doses. No extraordinary storage temperatures required.
Australia has done phase 3 clinical trials on several vaccines. Nobody has made any public fuss about the results of any of them - except for the Univ ersity of Queensland vaccine, which happened to produce false positives to an HIV test - completely inconsequential, but enough to get it canned.
I don't know how important it is how effective the vaccine is if enough peo ple don't take it. A friend in a retirement home said that something like
40% of the workers don't want the vaccine! If that's the opinion of our he alth care workers, what is the general population going to do?
The world is full of idiots. Maybe it wasn't just Trump bringing everyone' s IQ down, maybe most people really are the stupid!? I guess this may end up being a Darwinian event.
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Rick C.
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iant was detected in more than half of the Covid-19 cases recorded, with th e vaccine candidate shown to be 95.6 per cent effective against the origina l strain and 85.6 per cent effective against the variant.
per cent aged over 65.
ntigen was not optimized for it, but the results are still in the WOW categ ory.
round $6 per dose. Australia is completely sold on it on the basis of their experience in trials there and the advice of their senior immunologists, a nd recently ordered an additional 10 million doses. No extraordinary storag e temperatures required.
s made any public fuss about the results of any of them - except for the Un iversity of Queensland vaccine, which happened to produce false positives t o an HIV test - completely inconsequential, but enough to get it canned.
You're not on top of anything going on there so you wouldn't know, but ther e's quite a bit of excitement over it.
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Immune response results thus far also bode well for lasting immunity, such as it is with all the variants unfolding.
ariant was detected in more than half of the Covid-19 cases recorded, with the vaccine candidate shown to be 95.6 per cent effective against the origi nal strain and 85.6 per cent effective against the variant.
27 per cent aged over 65.
antigen was not optimized for it, but the results are still in the WOW cat egory.
Wacky Oddly-Justified Weirdness?
around $6 per dose. Australia is completely sold on it on the basis of the ir experience in trials there and the advice of their senior immunologists, and recently ordered an additional 10 million doses. No extraordinary stor age temperatures required.
has made any public fuss about the results of any of them - except for the University of Queensland vaccine, which happened to produce false positives to an HIV test - completely inconsequential, but enough to get it canned.
ere's quite a bit of excitement over it.
I'm not on top any stock market hype. People who want to sell share before the unfortunate reality gets widely known do pretend to know a lot of excit ing things. You do seem to get wound up by people like that.
h as it is with all the variants unfolding.
What would current results tell us about lasting immunity? The virus has on ly be around for a bit over a year, and all the vaccines are quite a bit mo re recent.
None of the immunity being observed has lasted for more than few months, so the "well-boding" is pure guess work.
variant was detected in more than half of the Covid-19 cases recorded, wit h the vaccine candidate shown to be 95.6 per cent effective against the ori ginal strain and 85.6 per cent effective against the variant.
h 27 per cent aged over 65.
ke antigen was not optimized for it, but the results are still in the WOW c ategory.
en around $6 per dose. Australia is completely sold on it on the basis of t heir experience in trials there and the advice of their senior immunologist s, and recently ordered an additional 10 million doses. No extraordinary st orage temperatures required.
y has made any public fuss about the results of any of them - except for th e University of Queensland vaccine, which happened to produce false positiv es to an HIV test - completely inconsequential, but enough to get it canned .
there's quite a bit of excitement over it.
e the unfortunate reality gets widely known do pretend to know a lot of exc iting things.
uch as it is with all the variants unfolding.
only be around for a bit over a year, and all the vaccines are quite a bit more recent.
so the "well-boding" is pure guess work.
Guess work, of course, duh, but pure? no. The statement is based upon my re ading of research summary done on the original SARS-CoV persistence of immu nity in survivors. Link? Not a chance.
"Health Care Worker" covers everyone from surgeons and other specialists down to the person who sweeps the ward floor. I doubt that aged care demands only the best and brightest, so I don't know that one can read too much into the number of health care workers who don't want to be vaccinated.
people don't take it. A friend in a retirement home said that something li ke 40% of the workers don't want the vaccine! If that's the opinion of our health care workers, what is the general population going to do?
ne's IQ down, maybe most people really are the stupid!? I guess this may en d up being a Darwinian event.
I'm not sure you understand the point being made. There is no reason to th ink health care workers are any less intelligent than the average person. So if 40% of the general population don't get the vaccine and the vaccine i s only 95% effective... at best given the various strains of the virus whic h seem to be less thwarted by it, we may only see an effective immunity of closer to 50% or even less. While this will clearly slow the transmission rate of the disease somewhat, it is not enough to eradicate it. We can exp ect the R value to still be above 1.0.
I think it's reasonable to say the general population has faith that the va ccine will simply put an end to the pandemic whether they personally get th e vaccine or not. Then there are many who simply have no interest because they aren't "afraid" of this disease or don't believe it is real. I know where I am plenty of people enter public places without a mask. Do you thi nk they are going to get the vaccine? This country is f***ed up badly and I know exactly who f***ed it up so badly.
--
Rick C.
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ew variant was detected in more than half of the Covid-19 cases recorded, w ith the vaccine candidate shown to be 95.6 per cent effective against the o riginal strain and 85.6 per cent effective against the variant.
ith 27 per cent aged over 65.
pike antigen was not optimized for it, but the results are still in the WOW category.
been around $6 per dose. Australia is completely sold on it on the basis of their experience in trials there and the advice of their senior immunologi sts, and recently ordered an additional 10 million doses. No extraordinary storage temperatures required.
ody has made any public fuss about the results of any of them - except for the University of Queensland vaccine, which happened to produce false posit ives to an HIV test - completely inconsequential, but enough to get it cann ed.
t there's quite a bit of excitement over it.
ore the unfortunate reality gets widely known do pretend to know a lot of e xciting things.
such as it is with all the variants unfolding.
s only be around for a bit over a year, and all the vaccines are quite a bi t more recent.
, so the "well-boding" is pure guess work.
reading of research summary done on the original SARS-CoV persistence of im munity in survivors. Link? Not a chance.
This is from the guy who told us that receptor-binding domain in the Covid-
19 genome hadn't mutated in the eleven months (as it was then) since the fi rst genome for the virus had been published. Fred's capacity to read stuff and get the wrong message is truly remarkable.
With that kind of performance in his history it isn't surprising that's he is reluctant to reveal what he's currently misapprehending.
new variant was detected in more than half of the Covid-19 cases recorded, with the vaccine candidate shown to be 95.6 per cent effective against the original strain and 85.6 per cent effective against the variant.
with 27 per cent aged over 65.
spike antigen was not optimized for it, but the results are still in the W OW category.
s been around $6 per dose. Australia is completely sold on it on the basis of their experience in trials there and the advice of their senior immunolo gists, and recently ordered an additional 10 million doses. No extraordinar y storage temperatures required.
obody has made any public fuss about the results of any of them - except fo r the University of Queensland vaccine, which happened to produce false pos itives to an HIV test - completely inconsequential, but enough to get it ca nned.
but there's quite a bit of excitement over it.
efore the unfortunate reality gets widely known do pretend to know a lot of exciting things.
y, such as it is with all the variants unfolding.
has only be around for a bit over a year, and all the vaccines are quite a bit more recent.
hs, so the "well-boding" is pure guess work.
y reading of research summary done on the original SARS-CoV persistence of immunity in survivors. Link? Not a chance.
d-19 genome hadn't mutated in the eleven months (as it was then) since the first genome for the virus had been published. Fred's capacity to read stuf f and get the wrong message is truly remarkable.
e is reluctant to reveal what he's currently misapprehending.
Nobody said anything about the genome not mutating, the statement was about the RBD, or significant portions of it, not mutating. Then look what happe ned after that. Many tens of billions $ commitment to a massive effort of c utting edge vaccine development was undertaken precisely based upon that pr emise. It takes a seriously psychopathic narcissist of extreme ignorance to fantas ize at your level of intensity. You can't understand a bit of the science, or any other science for that matter. It's all anybody can do to teach you algorithms and simple rules, you can't develop anything remotely close to c oherent understanding of anything.
he new variant was detected in more than half of the Covid-19 cases recorde d, with the vaccine candidate shown to be 95.6 per cent effective against t he original strain and 85.6 per cent effective against the variant.
4, with 27 per cent aged over 65.
ir spike antigen was not optimized for it, but the results are still in the WOW category.
has been around $6 per dose. Australia is completely sold on it on the basi s of their experience in trials there and the advice of their senior immuno logists, and recently ordered an additional 10 million doses. No extraordin ary storage temperatures required.
Nobody has made any public fuss about the results of any of them - except for the University of Queensland vaccine, which happened to produce false p ositives to an HIV test - completely inconsequential, but enough to get it canned.
, but there's quite a bit of excitement over it.
before the unfortunate reality gets widely known do pretend to know a lot of exciting things.
ity, such as it is with all the variants unfolding.
s has only be around for a bit over a year, and all the vaccines are quite a bit more recent.
nths, so the "well-boding" is pure guess work.
my reading of research summary done on the original SARS-CoV persistence o f immunity in survivors. Link? Not a chance.
vid-19 genome hadn't mutated in the eleven months (as it was then) since th e first genome for the virus had been published. Fred's capacity to read st uff and get the wrong message is truly remarkable.
he is reluctant to reveal what he's currently misapprehending.
ut the RBD, or significant portions of it, not mutating.
The genome is the program, and the bit that programs the animo-acid sequenc e in the receptor-bidnoig domain on the spike protein does mutate just as o ften as any other part of the genome. Most such mutations mean that mutant strain can't infect new cells and can't reproduce, so it dies out immediat ely. This makes the region "highly conserved". Some of these mutations are inconsequential and had survive to be observed, and you didn't know about it.
You don't seem to be able to understand what's actually going on, no mater how carefully it gets explained to you.
a massive effort of cutting edge vaccine development was undertaken precis ely based upon that premise.
The premise was that region was highly conserved, not that it didn't mutate . You don't seem to be able to grasp the difference.
Some of the vaccines under development do aim to exploit this, At one point you claimed that all of them did, and I had no trouble finding examples th at didn't.
And we already put millions of dollars into developing flu vaccines that on ly work on particular strains of flu and get superseded in a year or so. Co vid-19 doesn't mutates as fast as fly ( if a lot more rapidly than DNA viru ses do) so it makes even more sense to develop vaccines against it.
asize at your level of intensity.
You seem to be describing yourself here.
atter.
Your limitations aren't as drastic as that, but you aren't well-placed to c laim that other people can't understand the science, What you seem to be sa ying is that anybody who won't agree with your delusions has to be wrong ab out everything.
't develop anything remotely close to coherent understanding of anything.
Fred does seem to want to teach us simple rules that happen to be wrong and dangerously misleading. When he can't get the kind of reaction he wants he gets testy.
On Saturday, January 30, 2021 at 10:02:49 PM UTC-5, Bill Sloman wrote:
:
ote:
wrote:
wrote:
the new variant was detected in more than half of the Covid-19 cases recor ded, with the vaccine candidate shown to be 95.6 per cent effective against the original strain and 85.6 per cent effective against the variant.
84, with 27 per cent aged over 65.
heir spike antigen was not optimized for it, but the results are still in t he WOW category.
r has been around $6 per dose. Australia is completely sold on it on the ba sis of their experience in trials there and the advice of their senior immu nologists, and recently ordered an additional 10 million doses. No extraord inary storage temperatures required.
s. Nobody has made any public fuss about the results of any of them - excep t for the University of Queensland vaccine, which happened to produce false positives to an HIV test - completely inconsequential, but enough to get i t canned.
ow, but there's quite a bit of excitement over it.
re before the unfortunate reality gets widely known do pretend to know a lo t of exciting things.
unity, such as it is with all the variants unfolding.
rus has only be around for a bit over a year, and all the vaccines are quit e a bit more recent.
months, so the "well-boding" is pure guess work.
on my reading of research summary done on the original SARS-CoV persistence of immunity in survivors. Link? Not a chance.
Covid-19 genome hadn't mutated in the eleven months (as it was then) since the first genome for the virus had been published. Fred's capacity to read stuff and get the wrong message is truly remarkable.
's he is reluctant to reveal what he's currently misapprehending.
bout the RBD, or significant portions of it, not mutating.
nce in the receptor-bidnoig domain on the spike protein does mutate just as often as any other part of the genome. Most such mutations mean that mutan t strain can't infect new cells and can't reproduce, so it dies out immedia tely. This makes the region "highly conserved". Some of these mutations are inconsequential and had survive to be observed, and you didn't know about it.
The RBD is a protein complex, not genetic material. The composition of the complex is directed by the genetic sequence. The term conserved means the p rotein complex remains the same. Mutation refers to changes in the genetic sequence. I'm not going to waste time discussing oversimplified definitions and semantics. Your claim that the idea of the RBD staying conserved was " wrong" is deflated by the all the effort of the pharmaceutical industry to develop a vaccine that goes after the RBD. Those people know far more about the subject than you're capable of imagining. And genomic mutation and the estimate of its stability is far more complex than you know. There are seq uences of nucleotides that are more stable than others and there are enzyme s at play. It is known the SARS-CoV-2 has a "proofreading" enzyme that exci ses mutations making the effective mutation rate very small. This fact and many others went into the assessment of stability of the RBD and was fully taken into account before launching what has become a massive development e ffort. And no one is interested in your simple minded, untutored ideas of viral ev olution either. The modern world is a pharmaceutical minefield looking to e xplode any and all attempts to breach it. This is THE main reason for mutat ions they're seeing. Not here to debate this, just to tell you. Debating w ith you is like trying to communicate with a tree monkey in a zoo. oooo-ooo o-hooo-hoooo.
r how carefully it gets explained to you.
to a massive effort of cutting edge vaccine development was undertaken prec isely based upon that premise.
te. You don't seem to be able to grasp the difference.
nt you claimed that all of them did, and I had no trouble finding examples that didn't.
only work on particular strains of flu and get superseded in a year or so. Covid-19 doesn't mutates as fast as fly ( if a lot more rapidly than DNA vi ruses do) so it makes even more sense to develop vaccines against it.
ntasize at your level of intensity.
matter.
claim that other people can't understand the science, What you seem to be saying is that anybody who won't agree with your delusions has to be wrong about everything.
an't develop anything remotely close to coherent understanding of anything.
nd dangerously misleading. When he can't get the kind of reaction he wants he gets testy.
ed the new variant was detected in more than half of the Covid-19 cases rec orded, with the vaccine candidate shown to be 95.6 per cent effective again st the original strain and 85.6 per cent effective against the variant.
to 84, with 27 per cent aged over 65.
their spike antigen was not optimized for it, but the results are still in the WOW category.
far has been around $6 per dose. Australia is completely sold on it on the basis of their experience in trials there and the advice of their senior im munologists, and recently ordered an additional 10 million doses. No extrao rdinary storage temperatures required.
nes. Nobody has made any public fuss about the results of any of them - exc ept for the University of Queensland vaccine, which happened to produce fal se positives to an HIV test - completely inconsequential, but enough to get it canned.
know, but there's quite a bit of excitement over it.
hare before the unfortunate reality gets widely known do pretend to know a lot of exciting things.
mmunity, such as it is with all the variants unfolding.
virus has only be around for a bit over a year, and all the vaccines are qu ite a bit more recent.
w months, so the "well-boding" is pure guess work.
upon my reading of research summary done on the original SARS-CoV persisten ce of immunity in survivors. Link? Not a chance.
e Covid-19 genome hadn't mutated in the eleven months (as it was then) sinc e the first genome for the virus had been published. Fred's capacity to rea d stuff and get the wrong message is truly remarkable.
at's he is reluctant to reveal what he's currently misapprehending.
about the RBD, or significant portions of it, not mutating.
uence in the receptor-binding domain on the spike protein does mutate just as often as any other part of the genome. Most such mutations mean that mut ant strain can't infect new cells and can't reproduce, so it dies out immed iately. This makes the region "highly conserved". Some of these mutations a re inconsequential and had survive to be observed, and you didn't know abou t it.
e complex is directed by the genetic sequence.
That's what I just said.
And changing the genetic sequence changes the amino-acid sequences in the p roteins produced by the genome. Change the relevant bit of genome and you c hange the protein.
mantics.
Because you don't understand them and make an ass of yourself when you try to pretend that you do.
ated by the all the effort of the pharmaceutical industry to develop a vacc ine that goes after the RBD. Those people know far more about the subject t han you're capable of imagining.
And more than you seem to be able to understand, granting the hash you make when you try to tell us about it.
x than you know.
This is one more of your pretentious and unsubstantiated claims. Why do you bother wasting bandwidth on them?
here are enzymes at play.
Wow. More word salad.
ions making the effective mutation rate very small.
As I've mentioned repeatedly. The effective mutation rate of Covid-19 is sm all for a RNA virus, but still higher than you would see in a DNA virus.
and was fully taken into account before launching what has become a massiv e development effort.
Twaddle. Some people tried to make a vaccine which specifically targeted th e receptor-binding domain of the spike protein. Most didn't.
evolution either. The modern world is a pharmaceutical minefield looking to explode any and all attempts to breach it. This is THE main reason for mut ations they're seeing.
Bizarre insanity.
You are here to spout your fatuous twaddle. To debate it you'd have to hav e some idea of what you were talking about, and you clearly don't.
o. oooo-oooo-hooo-hoooo.
Your hoots are a hoot. Sadly, it's you that seems to be the tree monkey her e.
ter how carefully it gets explained to you.
t to a massive effort of cutting edge vaccine development was undertaken pr ecisely based upon that premise.
tate. You don't seem to be able to grasp the difference.
oint you claimed that all of them did, and I had no trouble finding example s that didn't.
t only work on particular strains of flu and get superseded in a year or so . Covid-19 doesn't mutates as fast as flu ( if a lot more rapidly than DNA viruses do) so it makes even more sense to develop vaccines against it.
fantasize at your level of intensity.
at matter.
to claim that other people can't understand the science, What you seem to b e saying is that anybody who won't agree with your delusions has to be wron g about everything.
can't develop anything remotely close to coherent understanding of anythin g.
and dangerously misleading. When he can't get the kind of reaction he want s he gets testy.
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