Step index has twice as many modes as graded-index with the same NA, so it's a win for light pipe applications.
Plastic fibre comes in sizes up to a couple of millimeters, and you can get bundles and liquid light guides that are much larger than that.
Things going on in vacuum chambers often produce a fair amount of UV, which may or may not make it through the windows. The 254-nm line of mercury is energetic enough to decompose plastic and darken quartz fibre over time.
Cheers
Phil Hobbs