FR4 is fine in the 50 ps ballpark; just keep things short, which happens naturally in fast stuff.
On a microstrip trace, most of the current is on the bottom of the trace, because the dielectric constant of FR4 is almost 5x that of air. So the top plating doesn't matter. What's worse than FR4 dielectric loss is the fact that normal PC boards have the bottom side of the copper crudded up with "black oxide" to improve adhesion of the copper to the epoxy. That multiplies the skin effect losses. Peel up a trace and see; it's disgusting.
For seriously high frequencies, you can buy low-loss low-Er dielectrics with microinch-smooth finish on both sides of the copper. The traces will peel off easily with an x-acto knife. That's what works well for RF stuff, like microstrip filters and LNAs, where skin losses cost noise figure.
We did one board that cleverly had microwave laminate for layer 1, then FR4 for the other layers. It curled up like a potato chip. If you laid it on a desk and gave it a good twirl, it would spin for a full minute.