In general, ISE 8.1i seems to install and work just fine on my Athlon 64 system running Fedora Core 4 (64-bit).
ISE Simulator does not seem to get installed, though. I'll try installing on a 32-bit system later and see if that gets it.
And unfortunately there still aren't 64-bit cable drivers for use with the Parallel Cable IV or the Platform Cable USB. I started trying to build them myself from the Xilinx "sources" and the Jungo demo kit, but Xilinx supplies the core of the XPC4 driver as a binary archive, and they don't supply a 64-bit version of that.
Sigh.
Could we have some 64-bit cable drivers, pretty please?
It's nice being able to run Project Navigator and do everything up through the programming file generation on my main development machine, instead of needing a second machine with very old software (RHEL3) for that. But it looks like I'll still need a second machine to run Impact.
I'm considering buying Chipscope, but I think I'll hold off until there are 64-bit cable drivers.