This one doesn't work by producing antibodies, it uses a virus vector to train T-cells to attack cells infected by the virus and thereby stem the proliferation of the infection.
An Oxford spin-off Vaccitech
If successful, it will still be the better part of a decade before the new vaccine becomes available.
It's funny how all these great advances are always ten years away, especially if you're gonna die before that without the treatment.
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This is not conjectural, the story is about clinical trials. Dunno about UK , but in U.S. that is three phases and a few years per phase. And it looks like this vaccine, if it pans out, will be made available only for those 65 yo or older once it's available, at least for a few years anyway, like mayb e two decades, and that's because they'll be wanting to collect more effica cy and safety data on that group, just a continuation of the trial whether they say it explicitly or not.
Re-targeting one's own immune system to eliminate some infected or diseased cells has been a long-standing goal.
The problem with all those so far is that they sometimes accidentally send an angry T-swarm off in the wrong direction, e.g. at your brain. Which turns out badly.
Cheers, James Arthur
There's nothing funny about it. Mass market medicines go through massive cl inical trials before they are allowed to go on open sale. It didn't stop Th alidomide from deforming a bunch of kids, nor Posicor (mibefradil) from kil ling about a hundred patients, but it's a balance between losing too many p atients from a drug that gets approved when it shouldn't have been and losi ng some patients who might have lived longer if a drug had been freely avai lable earlier.
-- Bill Sloman, Sydney
I wonder if that's why James Arthur thinks that the Tea Party is the best thing since sliced bread, and that universal health care isn't a good idea. A shortage of brain cells is a plausible explanation for both.
-- Bill Sloman, Sydney
snipped-for-privacy@gmail.com wrote on 1/16/2018 11:05 AM:
I didn't see this in the article. Rather they simply say the vaccine works by promoting production of T-cells.
"Crucially, the new vaccine stimulates the immune system to boost influenza-specific T-cells, instead of antibodies, that kill the virus as it tries to spread through the body."
Maybe you are thinking of a mechanism where a cell infected by the virus flags itself by pushing antigens to the cell surface so the cell can be attacked before many viruses can be made.
I don't see this in the article either. They say the vaccine has undergone the first phase of testing for safety.
-- Rick C Viewed the eclipse at Wintercrest Farms, on the centerline of totality since 1998
I can't explain every little thing to you. The article was written with some presumption of knowledge of vaccines on the part of the reader. It was an Oxford press release, not Engadget.
The brain damage and the possibility of Thompson's "natural immunity" being T-cell based, look like everything is coming together.
I didn't ask for explanation. I'm pointing out things that are being assumed as they were not stated in the article.
-- Rick C Viewed the eclipse at Wintercrest Farms, on the centerline of totality since 1998
Well, there is a "vaccine" that is fast acting and permanent.. ...a few ounces of lead moving at high velocity toward the heart
o train T-cells to attack cells infected by the virus and thereby stem the proliferation of the infection.
cine
new vaccine becomes available.
Preventing plagues by killing everybody who looks sick and burning the bodi es is a known technique, but not all that popular, or effective - people st art taking a lot of care not to look sick, and quite few diseases are infec tious long before you look sick. AIDS is an extreme example.
Tom Del Rosso does dredge up some very dubious ideas.
-- Bill Sloman, Sydney
Not necessarily. It might well *improve* some people - like Bill Sloman, for example.
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Cursitor Doom seems to have been "improved" by losing whatever capacity he ever had for critical thinking. Like Aesop's fox who lost his tail, he now thinks that everybody else should be "improved" in the same way, so that th ey'd all agree with the idiotic ideas that make him happy.
-- Bill Sloman, Sydney
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