Why Novavax's Coronavirus Vaccine Might Be First to Market

Attempting to accelerate the people x time product means HUGE trial enrollm ents that just aren't happening. And the volunteers are age restricted to 1

8-59, because most developers just plain don't want to know the results for older people. NOVAVAX has already expanded the age range out to 84.

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might-be-first-to/

There are a bunch of other outcomes the developers don't want to know too, but time is on their side for that kind of thing. No worries.

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bloggs.fredbloggs.fred
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lments that just aren't happening. And the volunteers are age restricted to 18-59, because most developers just plain don't want to know the results f or older people. NOVAVAX has already expanded the age range out to 84.

e-might-be-first-to/

, but time is on their side for that kind of thing. No worries.

It's a puff from website that promotes shares in particular companies to sp eculators.

Unlike Fred Bloggs, they do admit that Novavax isn't a front -runner, but c laim that it isn't too far behind the real front-runners.

They are looking to see at least one vaccine hitting the market under an em ergency use authorisation, and we can expect to see Donald Trump apply lot s of political pressure on the US Food and Drug Administration to get some kind of vaccine out in the field before the election in November.

US deaths from Covid-19 are now at 185,986, and a botched vaccination camp aign could kill even more.

It's all decidedly depressing. But Fred can't see anything to worry about.

--
Bill Sloman, Sydney
Reply to
Bill Sloman

ollments that just aren't happening. And the volunteers are age restricted to 18-59, because most developers just plain don't want to know the results for older people. NOVAVAX has already expanded the age range out to 84.

ine-might-be-first-to/

oo, but time is on their side for that kind of thing. No worries.

speculators.

claim that it isn't too far behind the real front-runners.

emergency use authorisation, and we can expect to see Donald Trump apply lo ts of political pressure on the US Food and Drug Administration to get some kind of vaccine out in the field before the election in November.

paign could kill even more.

.

More fact free opinionation from the park bench crowd....if you don't see a problem with a material requiring storage at -80oC then you're even dumber than you appear. And you're still too stupid to understand that state of p rogress in a bureaucratic process is almost meaningless. This is probably b ecause you're so ignorant you don't understand the process does not establ ish requirements on outcomes, other than safety. The U.S government gave a big chunk of their entire budget to NOVAVAX, yet you call this "hype?" Dumber than dumb.

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Reply to
Fred Bloggs

Novavax has never produced a vaccine before. I understood they made lots of promises over the years, but nothing has ever come of any of the hype.

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Great marketing department, lousy results. Much have bought off a lot of people to get that big an order totally on spec and non-performance in the past.

Sounds like another con job to me...

John :-#(#

Reply to
John Robertson

nrollments that just aren't happening. And the volunteers are age restricte d to 18-59, because most developers just plain don't want to know the resul ts for older people. NOVAVAX has already expanded the age range out to 84.

ccine-might-be-first-to/

too, but time is on their side for that kind of thing. No worries.

to speculators.

but claim that it isn't too far behind the real front-runners.

an emergency use authorisation, and we can expect to see Donald Trump apply lots of political pressure on the US Food and Drug Administration to get s ome kind of vaccine out in the field before the election in November.

campaign could kill even more.

out.

ee a problem with a material requiring storage at -80oC then you're even du mber than you appear. And you're still too stupid to understand that state of progress in a bureaucratic process is almost meaningless. This is probab ly because you're so ignorant you don't understand the process does not est ablish requirements on outcomes, other than safety.

yet you call this "hype?" Dumber than dumb.

That's true of all the lead developers. One reason for that is they've all gone after the really tough viruses.

/

They're not marketing to the general public so your comments are irrelevant . As for the government, all advanced technology development has an expecta tion of failure. So much so that successful outcome is not just a surprise but a shock.

Reply to
Fred Bloggs

With zero success. So why is the US government still throwing lots of money at them?

No, they are marketing to the US Gov. and pretty successfully it seems to me.

Let's see, many years of promises, no positive results and this is a successful company that the Gov should invest in? Name other companies with no products ever brought to market that would survive as long.

This would be a boondoggle in any other industry, so why not here?

John :-#(#

Reply to
John Robertson

enrollments that just aren't happening. And the volunteers are age restric ted to 18-59, because most developers just plain don't want to know the res ults for older people. NOVAVAX has already expanded the age range out to 84 .

ow too, but time is on their side for that kind of thing. No worries.

s to speculators.

, but claim that it isn't too far behind the real front-runners.

r an emergency use authorisation, and we can expect to see Donald Trump app ly lots of political pressure on the US Food and Drug Administration to get some kind of vaccine out in the field before the election in November.

n campaign could kill even more.

about.

see a problem with a material requiring storage at -80oC then you're even dumber than you appear. And you're still too stupid to understand that stat e of progress in a bureaucratic process is almost meaningless. This is prob ably because you're so ignorant you don't understand the process does not e stablish requirements on outcomes, other than safety.

, yet you call this "hype?" Dumber than dumb.

ts

pe.

all gone after the really tough viruses.

There could be lots of reasons. They would continue to receive funding if t hey're taking new approaches and evolving their technology.

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vant. As for the government, all advanced technology development has an exp ectation of failure. So much so that successful outcome is not just a surpr ise but a shock.

Moderna, Inovio, BioNTech- not business but Oxford Jenner is another histo ry of total failure.

U.S. policy is for the government to step in and fund the long shots when t he payoff is important. Vaccines are minuscule compared to some of the othe r long shot technologies they fund.

Reply to
Fred Bloggs

Fair enough, I can accept that explanation. Thank you!

John :-#)#

Reply to
John Robertson

nrollments that just aren't happening. And the volunteers are age restricte d to 18-59, because most developers just plain don't want to know the resul ts for older people. NOVAVAX has already expanded the age range out to 84.

ccine-might-be-first-to/

too, but time is on their side for that kind of thing. No worries.

o speculators.

ut claim that it isn't too far behind the real front-runners.

n emergency use authorisation, and we can expect to see Donald Trump apply lots of political pressure on the US Food and Drug Administration to get so me kind of vaccine out in the field before the election in November.

ampaign could kill even more.

ut.

a problem with a material requiring storage at -80oC then you're even dumb er than you appear.

It's an obvious problem, but scarcely an insoluble one in an advanced indus trial country, where liquid nitrogen is distributed in truck loads at about the same price per litre as milk.

aucratic process is almost meaningless.

And you are stupid enough to believe that? Bureaucracy exists to get things done. They spend most of their time stopping stuff happening, mostly with good reason, but if they stopped everything they'd be dismantled, and if th ey stopped the wrong stuff too often they'd suffer the same fate.

ess does not establish requirements on outcomes, other than safety.

Effectiveness does come into it.

t you call this "hype?" Dumber than dumb.

Have you read the wikipedia article? "Operation Warp Speed agreed to pay $1 .6 billion to Novavax if clinical trials are successful to produce 100 mill ion doses of its candidate vaccine". The phrase "if clinical trials are suc cessful" seems to have evaded your attention.

The US government may have committed a sizeable chunk of their entire budge t, but the web page is unspecific about what they have actually spent.

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said six weeks ago, that they had spent some $4 billion by then, but hadn't published any details of how and where they have spent it.

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is more recent - 17th August - but has much the same concerns.

Since the operation does seem to be run by an industry insider - which is s tandard operating procedure for Trump - it looks rather like a pork barrel operation, where Trump is spending a lot of government money in a way that allows him to claim that he's doing something about the Covid-19 epidemic, while making well-heeled potential contributors to his election campaign ev en better-heeled and more likely to contribute to get him re-elected.

I may be being excessively cynical, but it's difficult to be excessively cy nical about Trump's activities - he's a remarkably brazen crook, even by US standards.

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Bill Sloman, Sydney
Reply to
Bill Sloman

e:

:

lots

hype.

Not true.

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they're taking new approaches and evolving their technology.

The obvious reason is that Donald Trump is behind in the polls and at risk of getting kicked out in November. His handling of the Covid-19 epidemic ha s been dire, and he badly needs a vaccine - or something equally attention getting - before the US votes in November. Operation Warp Speed might deliv er that.

It also puts a lot of money in the pockets of people who might be willing t o contribute to Trump's election spending.

texas/

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levant.

It's not the general public who are putting up the money, and the marketing department will have been concentrating its attention on the individuals w ho are dishing out that money. Fred's ideas about relevance are decidedly o dd.

tation of failure. So much so that successful outcome is not just a surpris e but a shock.

In fact they are selling to Donald Trump and his team, who badly need a suc cess that they can sell to the electorate before the US votes on whether to keep that particular team in power in November. That rather encourages sho rt term thinking and aggressive risk-taking.

ory of total failure.

the payoff is important. Vaccines are minuscule compared to some of the ot her long shot technologies they fund.

They do tend to step in when they can fund something that might be impressi ve and might win them the next election. Reagan's Star War's expenditures w ere the same kind of boondoggle. Eisenhower wasn't happy with the way the m ilitary-industrial complex colluded to get huge expenditures on dubious wea pon systems, and Mary Kaldor nailed that back in 1980.

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If the program delivers a vaccine that works - and delivers it fast - it wo n't be a con job. That's not a particularly likely outcome - most vaccines that go to phase 3 clinical trials end up failing. Donald Trump badly needs a success to let him have much chance of being re-elected in November, an d if he can get the vaccine distributed before it has had chance to fail, i t could do what he needs, even if it doesn't save all that many lives, and delays the introduction of a more effective vaccine

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Bill Sloman, Sydney
Reply to
Bill Sloman

enrollments that just aren't happening. And the volunteers are age restric ted to 18-59, because most developers just plain don't want to know the res ults for older people. NOVAVAX has already expanded the age range out to 84 .

ow too, but time is on their side for that kind of thing. No worries.

to speculators.

but claim that it isn't too far behind the real front-runners.

an emergency use authorisation, and we can expect to see Donald Trump appl y lots of political pressure on the US Food and Drug Administration to get some kind of vaccine out in the field before the election in November.

campaign could kill even more.

bout.

ee a problem with a material requiring storage at -80oC then you're even du mber than you appear.

ustrial country, where liquid nitrogen is distributed in truck loads at abo ut the same price per litre as milk.

reaucratic process is almost meaningless.

gs done. They spend most of their time stopping stuff happening, mostly wit h good reason, but if they stopped everything they'd be dismantled, and if they stopped the wrong stuff too often they'd suffer the same fate.

More of your stupid generalizing.

ocess does not establish requirements on outcomes, other than safety.

yet you call this "hype?" Dumber than dumb.

$1.6 billion to Novavax if clinical trials are successful to produce 100 mi llion doses of its candidate vaccine". The phrase "if clinical trials are s uccessful" seems to have evaded your attention.

They just completed a Phase 2 in Australia and it was successful. Now they' re doing this Phase 2b thing in SA which is a much broader base of voluntee rs. If a problem develops, none of the other vaccine candidates will be abl e to say they wouldn't have the same problem because they're not testing fo r it.

get, but the web page is unspecific about what they have actually spent.

s/

't published any details of how and where they have spent it.

standard operating procedure for Trump - it looks rather like a pork barre l operation, where Trump is spending a lot of government money in a way tha t allows him to claim that he's doing something about the Covid-19 epidemic , while making well-heeled potential contributors to his election campaign even better-heeled and more likely to contribute to get him re-elected.

Actually Trump is doing as much as is possible.

WarpSpeed is chickenfeed. The majority of the money is set to be spent on m anufacturing, not development.

cynical about Trump's activities - he's a remarkably brazen crook, even by US standards.

Reply to
Fred Bloggs

AstraZeneca is manufacturing a vaccine, they're not a developer.

But just go ahead with your stupid act of pretending you've found me making a mistake. When you're the one who can't even read popular news with working comprehension. Go back to your park bench.

>
Reply to
Fred Bloggs

e:

rote:

ade lots

the hype.

ccine_1346885

Maybe, but they are still producing a vaccine. I don't bother doing exhaust ive searches on your more fatuously general claims - a single counter-examp le is enough to make the point

ng a mistake.

You make loads of mistakes. This was just one more in long list.

Which is to say I can notice when you misapprehend what the popular news is saying. John Larkin never admits it when he gets something wrong, and you do seem to have the same kind of problem. You really don't seem to be able to learn that "highly conserved" doesn't mean "doesn't mutate",

I haven't got one - there are parks around, and they do have benches - but I don't spend time sitting in any of them.

Your situation may be different.

--
Bill Sloman, Sydney
Reply to
Bill Sloman

al enrollments that just aren't happening. And the volunteers are age restr icted to 18-59, because most developers just plain don't want to know the r esults for older people. NOVAVAX has already expanded the age range out to

  1. > > > > >

know too, but time is on their side for that kind of thing. No worries.

es to speculators.

r, but claim that it isn't too far behind the real front-runners.

er an emergency use authorisation, and we can expect to see Donald Trump ap ply lots of political pressure on the US Food and Drug Administration to ge t some kind of vaccine out in the field before the election in November.

on campaign could kill even more.

about.

see a problem with a material requiring storage at -80oC then you're even dumber than you appear.

ndustrial country, where liquid nitrogen is distributed in truck loads at a bout the same price per litre as milk.

bureaucratic process is almost meaningless.

ings done. They spend most of their time stopping stuff happening, mostly w ith good reason, but if they stopped everything they'd be dismantled, and i f they stopped the wrong stuff too often they'd suffer the same fate.

Nowhere near as stupid as your generalisation that provoked it . "that stat e of progress in a bureaucratic process is almost meaningless"

What on earth was that supposed to mean? Bureaucratic processes are what r un the world - they have their problems, but if they didn't get things done they wouldn't be there.

process does not establish requirements on outcomes, other than safety.

, yet you call this "hype?" Dumber than dumb.

y $1.6 billion to Novavax if clinical trials are successful to produce 100 million doses of its candidate vaccine". The phrase "if clinical trials are successful" seems to have evaded your attention.

y're doing this Phase 2b thing in SA which is a much broader base of volunt eers. If a problem develops, none of the other vaccine candidates will be a ble to say they wouldn't have the same problem because they're not testing for it.

But we know that they are doing the Phase 2b trials in South Africa largely because it got them $15 million from the Bill and Melinda Gates Foundation . Theuy are stuck with using a broader base of volunteers, so they are natu rally making a virtue out of it. People wit more money and more options are n't bothering.

udget, but the web page is unspecific about what they have actually spent.

ers/

dn't published any details of how and where they have spent it.

is standard operating procedure for Trump - it looks rather like a pork bar rel operation, where Trump is spending a lot of government money in a way t hat allows him to claim that he's doing something about the Covid-19 epidem ic, while making well-heeled potential contributors to his election campaig n even better-heeled and more likely to contribute to get him re-elected.

As much as he imagines to be possible, and it's all aimed at getting himsel f re-elected in November

manufacturing, not development.

It's remarkably expensive chickenfeed. Manufacturing hundreds of millions o f doses of a vaccine is going to be even more expensive.

If the vaccine actually works it will be money well spent. Sadly, what Trum p wants the vaccine to do is to let him win in November.

The people paying for the production of the vaccine are more interested in getting one that protects them from Covid-19, which isn't of any importanc e to Donald Trump.

y cynical about Trump's activities - he's a remarkably brazen crook, even b y US standards.

--
Bill Sloman, Sydney
Reply to
Bill Sloman

:

rial enrollments that just aren't happening. And the volunteers are age res tricted to 18-59, because most developers just plain don't want to know the results for older people. NOVAVAX has already expanded the age range out t o 84.

o know too, but time is on their side for that kind of thing. No worries.

nies to speculators.

ner, but claim that it isn't too far behind the real front-runners.

nder an emergency use authorisation, and we can expect to see Donald Trump apply lots of political pressure on the US Food and Drug Administration to get some kind of vaccine out in the field before the election in November.

tion campaign could kill even more.

ry about.

't see a problem with a material requiring storage at -80oC then you're eve n dumber than you appear.

industrial country, where liquid nitrogen is distributed in truck loads at about the same price per litre as milk.

a bureaucratic process is almost meaningless.

things done. They spend most of their time stopping stuff happening, mostly with good reason, but if they stopped everything they'd be dismantled, and if they stopped the wrong stuff too often they'd suffer the same fate.

ate of progress in a bureaucratic process is almost meaningless"

run the world - they have their problems, but if they didn't get things don e they wouldn't be there.

It means exactly what it says. I don't off up explanations or links or argu ments.

e process does not establish requirements on outcomes, other than safety.

AX, yet you call this "hype?" Dumber than dumb.

pay $1.6 billion to Novavax if clinical trials are successful to produce 10

0 million doses of its candidate vaccine". The phrase "if clinical trials a re successful" seems to have evaded your attention.

hey're doing this Phase 2b thing in SA which is a much broader base of volu nteers. If a problem develops, none of the other vaccine candidates will be able to say they wouldn't have the same problem because they're not testin g for it.

ly because it got them $15 million from the Bill and Melinda Gates Foundati on. Theuy are stuck with using a broader base of volunteers, so they are na turally making a virtue out of it. People wit more money and more options a ren't bothering.

They get plenty of volunteers there, they're not stuck wih anything.

budget, but the web page is unspecific about what they have actually spent .

ayers/

hadn't published any details of how and where they have spent it.

h is standard operating procedure for Trump - it looks rather like a pork b arrel operation, where Trump is spending a lot of government money in a way that allows him to claim that he's doing something about the Covid-19 epid emic, while making well-heeled potential contributors to his election campa ign even better-heeled and more likely to contribute to get him re-elected.

elf re-elected in November

on manufacturing, not development.

of doses of a vaccine is going to be even more expensive.

Not really. The going price is about a billion for 100 million doses. That' s kinda compared to cost of the damage he vaccine will prevent.

ump wants the vaccine to do is to let him win in November.

All the candidate vaccines work. The problem is there's no reasonable idea of what "works" means.

n getting one that protects them from Covid-19, which isn't of any importan ce to Donald Trump.

Unlike you, Trump is looking at the big picture. The big picture is only a minuscule fraction of the population will be killed off by the virus, and m ost of them are not in the workforce to any essential degree. Regardless of the motive, Trump is in fact getting them the best vaccine th e science can provide at this time. And vaccines are not the end of it. The NIH is putting a ton of money into clinical treatments too. Lately Fauci seems most optimistic about monoclona l antibody therapy. This is much more potent than the plasma treatment rout e, which has lots of downsides they're not telling people about. The corona virus has fairly large replication rate. Meaning a single virus particle infecting a single cell causes the reproduction of about 1000 viri ons over a 10 hour period which get released from the cell to end up wherev er infecting more cells with ACE-2 receptors. The antibodies will need to c atch 999 of those to break even. And that's just a single virus particle. N obody has that many antibodies.

ely cynical about Trump's activities - he's a remarkably brazen crook, even by US standards.

Reply to
Fred Bloggs

te:

in getting one that protects them from Covid-19, which isn't of any import ance to Donald Trump.

a minuscule fraction of the population will be killed off by the virus, and most of them are not in the workforce to any essential degree.

Sadly Trump's "big picture" is all about whether he gets re-elected in Nove mber. He's ignoring the "miniscule fraction" that have been killed off so far - 187,701 US citizens and going up rapidly - because he couldn't care less.

the science can provide at this time.

He's much more interested in getting a vaccine that he can tweet about than getting one that will work. He want the best vaccine that he can tweet abo ut now, and whether it's effective is only interesting to the extent that i t shouldn't actively kill people in a way that it obvious;ly linked to the administration of the vaccine.

o clinical treatments too. Lately Fauci seems most optimistic about monoclo nal antibody therapy. This is much more potent than the plasma treatment ro ute, which has lots of downsides they're not telling people about.

It they can find the right antibody-generating cells to clone. The vaccines that are designed to provoke the production of antibodies to the highly co nserved receptor bonding domain of the spike protein are means to the same end.

s particle infecting a single cell causes the reproduction of about 1000 vi rions over a 10 hour period which get released from the cell to end up wher ever infecting more cells with ACE-2 receptors. The antibodies will need to catch 999 of those to break even. And that's just a single virus particle. Nobody has that many antibodies.

So nobody ever recovers from Covid-19?

Fred has posted some dumb claim here, but that one is dumber pretty much al l of the others

--
Bill Sloman, Sydney
Reply to
Bill Sloman

e:

e:

rote:

ed in getting one that protects them from Covid-19, which isn't of any impo rtance to Donald Trump.

y a minuscule fraction of the population will be killed off by the virus, a nd most of them are not in the workforce to any essential degree.

vember. He's ignoring the "miniscule fraction" that have been killed off so far - 187,701 US citizens and going up rapidly - because he couldn't care less.

e the science can provide at this time.

an getting one that will work. He want the best vaccine that he can tweet a bout now, and whether it's effective is only interesting to the extent that it shouldn't actively kill people in a way that it obvious;ly linked to th e administration of the vaccine.

nto clinical treatments too. Lately Fauci seems most optimistic about monoc lonal antibody therapy. This is much more potent than the plasma treatment route, which has lots of downsides they're not telling people about.

es that are designed to provoke the production of antibodies to the highly conserved receptor bonding domain of the spike protein are means to the sam e end.

Yeah? And then they clone this antibody in large numbers. What's your probl em?

rus particle infecting a single cell causes the reproduction of about 1000 virions over a 10 hour period which get released from the cell to end up wh erever infecting more cells with ACE-2 receptors. The antibodies will need to catch 999 of those to break even. And that's just a single virus particl e. Nobody has that many antibodies.

all of the others

Okay, thanks for falling for the bait. Your response is supposed to be: Hmm m... maybe there's more to it than just antibodies.

Well there is and they're called T- lymphocyte natural killer (NK) cells. T hese are white blood cells drawn to the site of cell infection by cytokines , recognize an infected cell by sensing bits of viral fusion protein on th e cell membrane, and then kill the cell, preventing any more viral replicat ion. In the first example, one antibody/ one virus particle, one NK cell/ 1000 v iral particles. The T-lymphocytes are what "clears" the host of the virus, antibodies don't do it. This phenomenon does have its drawbacks, things lik e destruction of nonregernative tissue. And in the case of COV it means per manent lung damage most commonly.

Reply to
Fred Bloggs

ote:

ote:

sted in getting one that protects them from Covid-19, which isn't of any im portance to Donald Trump.

nly a minuscule fraction of the population will be killed off by the virus, and most of them are not in the workforce to any essential degree.

November. He's ignoring the "miniscule fraction" that have been killed off so far - 187,701 US citizens and going up rapidly - because he couldn't car e less.

ine the science can provide at this time.

than getting one that will work. He want the best vaccine that he can tweet about now, and whether it's effective is only interesting to the extent th at it shouldn't actively kill people in a way that it obvious;ly linked to the administration of the vaccine.

into clinical treatments too. Lately Fauci seems most optimistic about mon oclonal antibody therapy. This is much more potent than the plasma treatmen t route, which has lots of downsides they're not telling people about.

ines that are designed to provoke the production of antibodies to the highl y conserved receptor bonding domain of the spike protein are means to the s ame end.

blem?

They don't clone the antibody. They clone the cell that generates the one they want. An antibody is a protein, and you can't clone proteins - what yo u can clone are cells. As usual you have said enough to demonstrate that yo u don't know what you are talking about.

virus particle infecting a single cell causes the reproduction of about 100

0 virions over a 10 hour period which get released from the cell to end up wherever infecting more cells with ACE-2 receptors. The antibodies will nee d to catch 999 of those to break even. And that's just a single virus parti cle. Nobody has that many antibodies.

ch all of the others.

mmm... maybe there's more to it than just antibodies.

Why? The problem is we want antibodies, and killer T-cells, that respectiv ely latch onto antigens expressed on Covid-19 virus particles, and antigens expressed on the surface of cells that have been infected by Covid-19 . G etting the right antigen into the body to provoke the production of both th ese defense mechanism is the problem.

Fauci doesn't seem to be talking about cloning Covid-19 specific killer T-c ells, so you've back-tracked on the effectiveness of the approach you seeme d to be touting.

viral particles. The T-lymphocytes are what "clears" the host of the virus , antibodies don't do it.

So what do antibodies do? They disable the targets they lock onto, and dire ct macrophages to chomp them up - which sounds very like clearing them from the body to me. You do seem to be peddling nonsense again.

ernative tissue. And in the case of COV it means permanent lung damage most commonly.

If the Covid-19 virus has infected enough lung cells in the first place

--
Bill Sloman, Sydney
Reply to
Bill Sloman

:

e:

rested in getting one that protects them from Covid-19, which isn't of any importance to Donald Trump.

only a minuscule fraction of the population will be killed off by the viru s, and most of them are not in the workforce to any essential degree.

n November. He's ignoring the "miniscule fraction" that have been killed of f so far - 187,701 US citizens and going up rapidly - because he couldn't c are less.

ccine the science can provide at this time.

t than getting one that will work. He want the best vaccine that he can twe et about now, and whether it's effective is only interesting to the extent that it shouldn't actively kill people in a way that it obvious;ly linked t o the administration of the vaccine.

ey into clinical treatments too. Lately Fauci seems most optimistic about m onoclonal antibody therapy. This is much more potent than the plasma treatm ent route, which has lots of downsides they're not telling people about.

ccines that are designed to provoke the production of antibodies to the hig hly conserved receptor bonding domain of the spike protein are means to the same end.

roblem?

they want. An antibody is a protein, and you can't clone proteins - what y ou can clone are cells. As usual you have said enough to demonstrate that y ou don't know what you are talking about.

e virus particle infecting a single cell causes the reproduction of about 1

000 virions over a 10 hour period which get released from the cell to end u p wherever infecting more cells with ACE-2 receptors. The antibodies will n eed to catch 999 of those to break even. And that's just a single virus par ticle. Nobody has that many antibodies.

much all of the others.

Hmmm... maybe there's more to it than just antibodies.

vely latch onto antigens expressed on Covid-19 virus particles, and antigen s expressed on the surface of cells that have been infected by Covid-19 . G etting the right antigen into the body to provoke the production of both th ese defense mechanism is the problem.

-cells, so you've back-tracked on the effectiveness of the approach you see med to be touting.

00 viral particles. The T-lymphocytes are what "clears" the host of the vir us, antibodies don't do it.

rect macrophages to chomp them up - which sounds very like clearing them fr om the body to me. You do seem to be peddling nonsense again.

egernative tissue. And in the case of COV it means permanent lung damage mo st commonly.

You're just an ignorant lowdown moron. You not only lack comprehension but have zero ability to learn anything new. For one thing, your ignorance tell s me you don't give a flying f_ck about any of the science involved, and ne ver did. So shut your f__king mouth and go away. You're not impressing anyo ne.

Reply to
Fred Bloggs

:

te:

e:

ote:

t have zero ability to learn anything new. For one thing, your ignorance te lls me you don't give a flying f_ck about any of the science involved, and never did. So shut your f__king mouth and go away. You're not impressing an yone.

And what this tells me - once again - is that you not only don't know muc h about the science involved. but also that you tend to react unpleasantly when your own pretensions are shown up (which doesn't take much insight, if more than you seem to have).

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Bill Sloman, Sydney
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Bill Sloman

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