People often lose sight of the fact that medicine is *practiced* (OTOH, science is *done*). What is *known* would fill a large library! What
*isn't* would fill the LoC! :-/It was only a few generations ago that 45 was "old age".
SWMBO is "finally" on a statin having been borderline for many years. We "fought" initial attempts to get her on meds by countering with dietary changes (bringing her numbers from "way too high" down to the high end of the "permissible" range in very short order).
While unhappy with this decision, she's agreed to try it for a few months -- giving due notice to the MD that if the side effects manifest, she'll discontinue the meds and "take her chances".
[It's important to remember that *something* is going to "get you", regardless!]It also depends a lot on what the consequences (those without the meds *and* any side effects *with* the meds) happen to be!
E.g., I have reasonably severe "seasonal allergies". The consequences of doing nothing for them leave me very uncomfortable, unable to sleep, struggling for "air", etc. (but, don't directly threaten my *life*!).
OTOH, some of the side effects of the meds are worse than (or identical to!) the symptoms they intend to alleviate! (Warning: May cause difficulty breathing, runny nose, irritated eyes...)
[I did a year or two of SLIT and found that somewhat effective -- with very little downside risk. Stopping that protocol *seemed* to allow me to reap continued benefits for another year or so. But, of late, things seem to be getting back to their old levels (always hard with these sorts of things as you can't take a pill one day and compare to how you feel the *next* day, WITHOUT it!).There are incentives in certain groups to publish (instead of "practice").