I don't think that electronic- engineering courses prescribe designing only using integrated circuits - ICs just provide pre-connected transistors, that happen to work in situations that designers have to cope with quite often.
True.
Application notes can help, for particular applications. Some people can learn quite quickly from a limited amount of experience - others latch onto the NE555 and don't seem to want to learn how to use anything else,.
One of the things you learn is that some people are rotten at electronic design.
Considering the nut-cases who post here, both those papers from PNAS are decidedly on-topic for the group, though divorced from the electronic design that we are supposed to be posting about (and hardly ever do). Jan Panteltje doesn't strike me as one of our saner posters, so maybe he feels that he is being got at.