I've only once spec'd an LCD display in a product. I recall lots of different issues, criteria (transflexive, transmissive, high temperature, etc.). But, have largely forgotten most of those issues (IIRC, transmissive/transflexive/reflexive have to do with the treatment of the back of the display)
I recall response time was sensitive to excitation voltage and temperature. I don't recall frequency being particularly critical. And, I know that duty cycle isn't, either (there are hacks you can exploit by using different duty cycles on different segments)
Today, I had to troubleshoot an electrical problem on a friend's vehicle so took an el-cheapo DMM along with me to probe voltages, continuity, etc. Leaving it in the back of her car was an oversight as when I went to retrieve it, the display was uniformly "black" (not just the segment areas).
I've experienced this before and know that it "recovers" once cooled. But, it got me wondering what is actually happening (physically) inside the glass when this condition manifests?