Version 2.1 of the excellent Pulsonix PCB design package has just been released:
I've been helping to beta-test it for a couple of months. I t has lots of interesting new features including:
CADSoft Eagle import Associated parts Enhanced report generator Insulated wires Component height checking etc.
The downloadable demo has a 100 pin limit, but is otherwise fully functional.
Prices start at $1395 for 1000 pins. Full price information is available on the web site.