Most of my SMPS expertise comes from looking over the shoulders of competent people, but since I think I understand most of what they're doing I'll answer your questions:
- Yes
- As low as you want to design for. For really widely varying loads you should look for PWM controllers that'll do "pulse swallowing", i.e. they'll let you set up some minimum length pulse and not pulse at all when the load is light and the output too high.
- Yes and yes -- I've seen circuits that rely on this, and I've seen some issues come back and bite people.
- (and 3). You may want to look into a current-mode controller; this servos around the high current point on the output transformer as its inner loop -- but I don't know if you can get current-mode control _and_ pulse swallowing without some home-rolled circuitry.
- You might think about a 10:1 step-up output transformer with synchronous rectification BUT I may really be blowing smoke here, particularly with a 500V output. Synchronous rectification SMPS design is a real opportunity to become intimate with shoot-through and the Miller effect as applies to high-speed, high-power circuitry. I've seen it used for a switching amplifier that needed to provide AC at 5-20V RMS from a 40V source, and that was a big learning experience for the guy doing it and everyone around him.