I'd agree with EAGLE as a good option. It is true the UI takes a bit of getting used to. That has been greatly increased with the upgrade EAGLE 5. It is still different, but in a good way I would say. Before we distributed EAGLE, we used it for serious design work for many clients (and still do). We often have to use our customer's tools and I can honestly say that I normally come out of that still preferring EAGLE.
PROS:
1) Various licenses to match our need (free, Light, non-profit, standard, pro, educational, student, ...)2) And you can upgrade and only pay the difference (exception upgrade from light). That fact alone will save $1000's if you have plans to scale. CadSoft doesn't advertise this enough, IMHO. Upgrades are a very minimum cost. The highest license cost $280 to upgrade to EAGLE 5. A paid upgrade cycle is about 3 years. Currently full new license is about $1500US. So all in all it is quite reasonable for what you get.
3) Common database between schematic and board--no forward and backward annotation. If you use the tool correctly the two are always in sync. This saves no end of headache and time.4) Fully documented access to all design info through their own User Language Program. Very powerful. Hopefully it will be extended even further, but it is certainly pretty useful. We have a suite of tools in the process of being released for EAGLE that are based on this.
5) Are you used to certain shortcuts? Modify all the shortcuts in EAGLE to whatever you like. They still need to allow use of Page Up/Down and arrow keys, but what is currently available is very flexible. Anything you can do in the tool can be scripted and anything you can script can be assigned to a key sequence.6) Binary file compatibility across Windows, Linux, and MacOSX (all native applications).
7) Free support for life. If you pay for a real license that includes phone support. And it's actually pretty good. And an involved community existed for further support.I'm not saying it's better than the big boys. But for about 80-90% of PCB's that are designed it is more than adequate. And another 5% can be done if you know what you are doing. Sure there are some boards that it can't do but I doubt very many people will hit that limit.
EAGLE 5 was released a few months ago and they are still working through a few bugs that caused.
Sales pitch: if you want to purchase a license you can do so at
Cheers,
James.