Yes. In tjeh Great Changeover when people were arguing their t*ts poof about 64 bit versos 32 bit. I just installed 64 bit because I could. I noticed no significant difference is speed, memory usage or disk space.
Some graphics heavy s*it was a bit faster
You cant really run a GUI on a Zero, once you get rid of that its got bags of RAM for a dedicated application, 32 or 64 bit e.g. $ free -m total used free shared buff/cache available Mem: 429 62 146 34 220 278 Swap: 99 0 99