Not so much guesswork as demanding of insight. If you haven't got any insight into how the thing works in its usual application, then you are reduced to guesswork.
Or read the data sheet with some insight into what might normally be going on.
Even marketing clown don't write data sheets that lead a lot of customers to blow up a lot of parts.
Asking the application engineer what might happen is less expensive, but means deferring to their expertise (when they have some).
<snipped the usual advertising>Not for grown-ups.