It's always the stupid things that cause the most trouble:
I was working on a fairly straightforward experimental audio circuit using TL074 op-amps laid out on Veroboard, which is prone to inter-track shorts unless you are very careful with your soldering. The gain of a virtual-earth stage was too high, so I altered some resistor values to cut it down.
As this was a stereo system, I experimented with one channel first and then switched off and replaced the equivalent resistors in the second channel (one of the other op-amps in the same chip).
The input signal was a 6 Kc/s sinwave at about -10 dBu. After the modification, the volume control, which was in a feedback loop, didnt seem to make much difference. Then I realised that applying the signal to the left channel gave a distorted version of it in the right channel and vice-versa. Obviously I had shorted two tracks somewhere - but where?
Things got even worse when I realised that the input signal was appearing on the virtual earth input of each op-amp, this definitely can't happen! I decided it was time to switch off the power supply and go and ponder the problem over a cup of tea.
That was the point where I discovered I hadn't switched the power supply on in the first place.