That is a possibility with certain software, so proceed with caution and always check that your backuped files are identical to the originals
*BEFORE* you need to restore from it.However in practice, there are few problems with this approach. Particularly as frequently changing files such the contents of caches are best excluded from incremental backups, and recreated when needed.
I have dozens of large sqlite databases which are receive updates during backups, and have not suffered any corrupted, verified by checking against remote replicated copies.
---druck