Been down to that computer museum in Mountain View a few times now, usally when work sends me to the San Jose area, so here's what I'd tell a first timer. Go early on a weekday if you can. Weekends get packed with families and you end up waiting to get close to the good stuff. Start with the old tube-based machines before you wander anywhere else. Seeing rows of vacuum tubes mounted on those big metal chassis behind glass is something photos never really capture. Look closely at the wiring looms and the labels on each panel, that's where the real craftsmanship shows. Give yourself at least half an hour there because there's a lot to take in.
One thing I wish I'd known the first visit: the docents are mostly old engineers who acutally worked on this equipment. Ask one a question and you'll get a twenty minute story, and it'll be the best twenty minutes of your day. Don't rush past the smaller exhibits on the way to the famous stuff either, some of the oddball homemade machines in the side cases are more interesting than the headline pieces. Wear comfy shoes, the place is bigger than it looks from the entrance.