While I claim spice is not a design tool, there are exceptions. One that comes to mind is sizing transistors. (This is specific to chip design.). If you need a device of a certain, for example, worst case on resistance, it would be proper to use the "weak file", crank up the temperature, set the worst case VGS, and then tweak the transistor width.
Similarly, if there was a minimum supply operating condition, it wouldn't be wrong to beef up a transistor in the weak model file at minimum operating temperature.
You could adjust op amp compensation in the strong file at minimum temp.