I had several failures in multiple batches of SMPS from a (normally) well- respected PSU manufacturer. The PCB layout artist had used a footprint with a square pad to indicate pin 1 on component (IIRC it was the switching FET) in the primary-side active PFC circuit. The clearance and creepage seemed adequate w.r.t. our interpretation of EN60950, but we think it was the sharp corner on that pad that pushed it over the edge.
The failures involved a lot of charred PCB and splashed solder, blown FETs and vaporised current sense resistors, so it was difficult to say exactly what initiated the breakdown, but in the units we investigated the damage was usually near the square pad.
The manufacturer assured us that the failures weren't their fault, of course.
Regards, Allan