Well, actually, yes there is - a number of video shooting games require CRT/Picture Tubes to work correctly. The reason is when the trigger is pulled the game sends a white square (or a single frame screen flash) to the screen that traces across each horizontal line as a marker for position. This is detected by the opto in the rifle/pistol and the time it is detected indicates where the gun was aimed...
The MAME emulations and the video upscalers don't do that well at all with picture tubes so those few games which use a photocell receptor in the pistol/rifle doesn't work with any LCD combo I have tried. I have not tried very many as it seemed an exercise in futility.
Otherwise the only other advantage of tubes over LCDs is the 3:4 aspect ratio is not easy to find in LCDs over 19". So pictures are squished a bit except for MAME emulations or upscalers that allow you to adjust the screen ratio.
Solutions in MAME involve changing the gun sensing position to use other external processes.
John :-#)#