...but probably not in any PC made since 2000. The only serial ports in them tend to be on additional PCI cards in case you hadn't noticed.
My main PC has no serial ports on its motherboard. Since I still have a few flight loggers and a GPS receiver or two that only have serial connections, I had to install a 6 serial port PCI card to it. This, course, has 16550s on it. However, in *this century* I've never needed to program a UART of any sort at the device register level or to know anything about it because all the systems I've needed to use serial comms on: various UNIces,Stratus,Linux and OS/9 already have excellent serial device drivers. So, why would I ever need to reinvent *that* wheel?