Any thoughts on attaching wire leads to very fine pitch IC's such as .5mm TSSOP's or even some of the leadless packages?
Yes, the right way to do prototypes is to make a board, or buy a breakout board with the right footprint.
But what about the wrong way to do it?
Wire wrap wire is just plain too large. Single strands of bare wire pulled out of standed cables can approach working, though soldering is tricky and they aren't insulated so have to be routed carefully.
Thought about using extremely fine heat-strippable magnet wire... tried unwinding a 32 ohm dollar-store headset but the wire kept breaking before I got much unwound.
Apparently the metallurgy of an actual wire bonding system is incompatible with tin-lead prepared leads.... (hmm, so how does it work inside the package - are those ends untinned? could one chemically strip the plating somehow?)
Anything workable with conductive epoxy perhaps?