OT: living a bit longer.

On Tuesday, February 20, 2018 at 10:57:00 PM UTC-5, snipped-for-privacy@ieee.org wrote :

Science has an interesting paper

fectious diseases rises with age.

t it take roughly six mutations in a cell line to make it cancerous.

he right figure, based on other data - and point out the human immune syste m works progressively worse as we get older, because the thymus gland gener ates progressively fewer T cells as we get older.

athematical model, they get a better fit to the cancer incidence curve at a bout 2.2 mutations.

for longer, we might live quite a bit longer. They do cite

from FOXN1-reprogrammed fibroblasts. Nat Cell Biol 16:902?908.

ody grow you a new, extra thymus gland from your own tissues (and have it i mplanted) whenever it looks as if you need one.

I think the more serious cancers exist because the tumors evade the immune system, healthy or not. The new CRISPR technology of genetically engineerin g the T-cells to attack the tumor shows the most promise.

te:

of Science has an interesting paper

infectious diseases rises with age.

hat it take roughly six mutations in a cell line to make it cancerous.

the right figure, based on other data - and point out the human immune sys tem works progressively worse as we get older, because the thymus gland gen erates progressively fewer T cells as we get older.

mathematical model, they get a better fit to the cancer incidence curve at about 2.2 mutations.

er for longer, we might live quite a bit longer. They do cite

d from FOXN1-reprogrammed fibroblasts. Nat Cell Biol 16:902?908.

ebody grow you a new, extra thymus gland from your own tissues (and have it implanted) whenever it looks as if you need one.

e system, healthy or not. The new CRISPR technology of genetically engineer ing the T-cells to attack the tumor shows the most promise.

I think the point of the paper is that you have less T-cells around as you get older, so the immune system is less likely catch the cancer cells befor e they get established.

Once the cancer is well-established enough to be detected and treated, it's a different (and much more expensive) ball game.

On Wednesday, February 21, 2018 at 9:54:52 AM UTC-5, snipped-for-privacy@ieee.org wrot e:

rote:

y of Science has an interesting paper

d infectious diseases rises with age.

that it take roughly six mutations in a cell line to make it cancerous.

to the right figure, based on other data - and point out the human immune s ystem works progressively worse as we get older, because the thymus gland g enerates progressively fewer T cells as we get older.

ir mathematical model, they get a better fit to the cancer incidence curve at about 2.2 mutations.

tter for longer, we might live quite a bit longer. They do cite

ted from FOXN1-reprogrammed fibroblasts. Nat Cell Biol 16:902?908.

omebody grow you a new, extra thymus gland from your own tissues (and have it implanted) whenever it looks as if you need one.

une system, healthy or not. The new CRISPR technology of genetically engine ering the T-cells to attack the tumor shows the most promise.

u get older, so the immune system is less likely catch the cancer cells bef ore they get established.

's a different (and much more expensive) ball game.

You missed the point. A healthy population of T-cells is not enough in many cases: " How tumors often evade tumor suppression mediated by innate killer cells is another major subject of the review."

ote:

emy of Science has an interesting paper

and infectious diseases rises with age.

is that it take roughly six mutations in a cell line to make it cancerous.

r to the right figure, based on other data - and point out the human immune system works progressively worse as we get older, because the thymus gland generates progressively fewer T cells as we get older.

heir mathematical model, they get a better fit to the cancer incidence curv e at about 2.2 mutations.

better for longer, we might live quite a bit longer. They do cite

rated from FOXN1-reprogrammed fibroblasts. Nat Cell Biol 16:902?908 .

somebody grow you a new, extra thymus gland from your own tissues (and hav e it implanted) whenever it looks as if you need one.

mmune system, healthy or not. The new CRISPR technology of genetically engi neering the T-cells to attack the tumor shows the most promise.

you get older, so the immune system is less likely catch the cancer cells b efore they get established.

it's a different (and much more expensive) ball game.

ny cases:

s is another major subject of the review."

No, you are still missing the point. More T-cells suppress potential tumour s more effectively than fewer T-cells.

It's all chance, so some tumours get away - even in otherwise healthy young people - but your chances are better if you have more T-cells.

At my age, an extra thymus (with less adipose tissue than the old one) woul d probably improve my chances no end.